Lien à explorer entre maladie de Parkinson et microbiote intestinale

Parkinson's Disease and the Gut Microbiota: A Link to Explore

Jul 02, 2023

Introduction to Parkinson's disease

Parkinson's disease is a neurological condition that affects millions of people around the world. It is primarily characterized by problems with mobility, balance, and muscle control, but can also lead to mood changes, gastrointestinal problems, and deterioration in memory and other cognitive functions. The exact causes of Parkinson's disease remain unclear and there is currently no cure for this condition.
References from the article " In Conversation: Why Parkinson's research is zooming in on the gut "

The role of the gut microbiota in Parkinson's disease

However, more and more research is focusing on the role of the gut microbiota in Parkinson's disease. According to Dr Ayse Demirkan, Senior Lecturer in AI Multiomics for Health and Wellbeing at the University of Surrey in the UK, the gut microbiota of people with Parkinson's disease is distinct and characterized by dysbiosis. , i.e. an imbalance between good and bad bacteria.

Braak's hypothesis

Braak's hypothesis suggests that an unknown pathogen can reach the brain through two routes, one of which involves the gut. According to this hypothesis, a pathogen could be ingested, reach the intestine, and then progress to the brain via the vagus nerve, the longest cranial nerve that connects the brain to the intestine, among others. This could then trigger the onset of Parkinson's disease.

The role of diet and exercise

However, although diet may help with gut dysbiosis, it remains unclear to what extent diet can actually alter the course of this disease. Some studies suggest that exercise may be an effective way to manage the symptoms of Parkinson's disease.


In conclusion, although the exact causes of Parkinson's disease remain unclear, there is a growing body of research suggesting a link between gut health and Parkinson's disease.

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