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Antiscar: A breakthrough in the treatment of ulcers and pressure sores
Healing ulcers and pressure sores remains a major challenge in the medical field, given the complexity of the healing process and the suffering patients endure. However, an innovative new treatment, developed by the French laboratory Naturveda, promises to change the situation. Understanding the Healing Process Ulcers and pressure sores are types of chronic wounds that can affect various parts of the body, particularly due to prolonged pressure on the skin and underlying tissues. These wounds are particularly common in older people or those who are immobilized for long periods of time. The wound healing process is extremely complex, involving various cells, proteins, and growth factors. A key component of this process is the extracellular matrix (ECM), which serves as a scaffold for cell regeneration and multiplication. Metalloproteinases (MMPs) are proteins that play a crucial role in the degradation of debris and impurities within the wound. However, in cases of ulcers and pressure ulcers, an imbalance occurs, leading to excessive release of MMPs, which destroys the ECM and hinders healing. Antiscar: A Revolution in the Treatment of Chronic Wounds Antiscar, the liquid bandage developed by Naturveda , is positioned as a promising solution to address this problem. The main objective of their research was to identify the specific MMPs involved in ECM degradation and to develop a way to selectively block them. After years of research and testing, Naturveda scientists identified two natural polymers that were able to bind specifically to target MMPs. These polymers were incorporated into a film-forming glycerol formulation, creating a liquid dressing that could create a stable protective film, while attracting contaminants to cleanse the wound. Additionally, honey has been added to the formulation due to its recognized healing properties. The combination of polymers, film-forming glycerol and honey provides a complete solution for optimal healing. Clinical Results and Commitment to the Medical Community Clinical results for Antiscar are promising, showing significant reduction in wound surface area and improvement in pain and moisture scores in just 21 days. Recognizing the crucial role of nurses in chronic wound management, Naturveda decided to partner with them, donating 2000 products for them to test Antiscar and provide their valuable feedback. Conclusion The innovation that Antiscar represents in the field of chronic wound healing is undeniable. By addressing the heart of the problem – excess MMP – and providing a comprehensive solution for ECM regeneration, Antiscar offers new and tangible hope for patients suffering from ulcers and pressure ulcers. With the support of the medical community and the direct involvement of nurses, the future of chronic wound healing looks brighter than ever.
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MIGSPRAY clinical study: A revolution against migraines
The ongoing research to combat migraines has seen a major breakthrough with the development of MIGSPRAY, an innovative and effective treatment. This breakthrough was made possible by the combination of research on parthenolide and technologies developed by the VITROBIO laboratory. MIGSPRAY Treatment MIGSPRAY is a class I medical device in the form of a nasal spray, intended for the prevention of migraine attacks. The natural active ingredients are included in a glycerol base, made film-forming thanks to the addition of specific polymers. Applied nasally, this film-forming glycerol maximizes the effects obtained in patients due to its osmotic properties. These allow fluids to be attracted to the outside once applied to the nasal mucosa, thus leading to the drainage of proteins involved in migraine such as CGRP, certain interleukins or TNF-alpha. Clinical Results Clinical results show that MIGSPRAY has remarkable efficacy. The study was divided into four main parts: Pathophysiology of Migraine: The study highlights the absence of specific preventive treatment for migraine, highlighting the importance of targeting pro-inflammatory proteins. In Vitro Study: It made it possible to justify the selection of specific polymers to target the proteins involved in triggering migraine attacks. Observational Clinical Study: Carried out on 256 patients, it showed a significant improvement in the prevention of migraine attacks. Randomized Double-Blind Clinical Study: Comparing MIGSPRAY to a placebo in 125 patients, it confirmed the efficacy of the treatment. Conclusion Clinical results highlight the efficacy of MIGSPRAY in reducing the number of migraine days per month, a significant improvement in HIT-6 and MIDAS scores, as well as excellent treatment tolerance with no serious side effects reported. These results make MIGSPRAY a revolutionary treatment option in the fight against migraines. Demographic Data and Clinical Study Results Demographic data showed no significant differences between treatment and placebo groups, ensuring a fair comparison. MIGSPRAY demonstrated a statistically significant reduction in the number of migraine days per month. 58% of patients in the treatment group experienced at least a 50% reduction in the average number of migraine days per month, compared to 24% in the placebo group. HIT-6 and MIDAS scores showed significant improvement in the treatment group compared to the placebo group. No serious side effects were reported, confirming the safety of the treatment. Side Effects and Safety MIGSPRAY was shown to be a safe treatment, with no serious side effects reported. The minor side effects observed showed no significant difference between the treatment and placebo groups, thus reinforcing confidence in the safety of the product. Conclusion MIGSPRAY represents a significant advance in migraine attack prevention, providing patients with a natural and effective treatment option. Clinical results strongly support its efficacy and safety profile, making MIGSPRAY a promising option for the millions of people affected by migraine worldwide. Link to the clinical study : https://www.openaccessjournals.com/articles/preventing-migraine-by-reducing-nasal-surface-contaminants--restoring-nasal-mucosa-integrity-clinical-efficacy-of-a-new-generation-16110.html
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HERBAMIG Study: Revolutionary Treatment for Migraines
To provide a holistic and natural approach to the fight against migraines, we have chosen not to limit ourselves to the exclusive use of parthenolide. Our research team has identified and incorporated a rigorous selection of natural active ingredients recognized for their benefits in the management of migraine symptoms. Among them, coenzyme Q10, a powerful antioxidant, salicin, a natural anti-inflammatory, as well as vitamins B12 and B2, all known for their role in reducing the frequency and intensity of migraine attacks. Synergy and innovation: MIG-RL (or HERBAMIG) In an innovative approach, we combined these ingredients with parthenolide to create MIG-RL (or HERBAMIG ), a unique formulation aimed at maximizing beneficial effects while minimizing potential side effects. This synergy was evaluated through a double-blind clinical study involving patients suffering from episodic migraines to validate its efficacy and safety of use. Clinical study: Methodology and promising results The study included 129 patients, all diagnosed for more than one year with migraine without aura, and meeting the criteria of the International Classification of Headache Disorders (ICHD-3:1.1). Baseline data were collected for 28 days before the start of the three-month treatment period, during which patients were randomly assigned to receive either HERBAMIG or placebo. The results revealed a significant mean reduction in the number of migraine days per month with HERBAMIG , compared to placebo. Additionally, nearly half of the patients treated with HERBAMIG experienced at least a 30% reduction in the mean number of migraine days per month, a result significantly superior to the placebo group. Importantly, MIG-RL was well tolerated by patients, with only minor side effects reported. Positive impact on stress and anxiety: a surprising discovery In addition to the beneficial effects observed on the frequency and intensity of migraine attacks, our HERBAMIG formulation revealed a notable ability to reduce stress and anxiety levels in patients participating in the clinical study. These results are particularly interesting and suggest that parthenolides, beyond their action on TRP receptors and pain, could exert an overall calming effect on brain activity. The precise mechanisms of this action remain the subject of in-depth research to this day, but it is plausible that the modification of the conformation of TRP receptors by parthenolides contributes to a positive modulation of neuronal activity, thus generating a state of calm and relaxation. This discovery opens exciting horizons for the potential use of HERBAMIG in the treatment of other conditions related to stress and anxiety, highlighting once again the richness and complexity of the interactions between natural compounds and our organism. Thus, HERBAMIG is not only positioned as a promising solution for migraine prevention, but also as a potential support in stress and anxiety management, helping to improve patients' quality of life on several levels. These results encourage our team to continue research and further explore the potential benefits of this innovative formulation, in the hope of offering a more holistic and caring approach to care. Conclusions and perspectives HERBAMIG, thanks to its synergistic combination of two plant extracts and other natural active ingredients, demonstrates a moderate effect in the prevention of migraines, stress and anxiety, without causing significant side effects. This formulation could represent a valuable additional help for some patients. However, further research and an improvement in the quality of the plants used are necessary to further optimize this natural and innovative solution. Link to the clinical study : https://www.auctoresonline.org/article/mig-rl-a-natural-preventive-treatment-against-migraine-outcomes-of-a-randomized-double-blind-clinical-trial
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Parthenolide: An in-depth study against migraines
After seeing the effectiveness of parthenolide on TRP receptor desensitization in our initial experiments, we decided to go further by formulating a concentrated parthenolide solution. Our goal was to specifically target migraine attacks, a severe and disabling form of headache, to reduce their frequency and intensity. Parthenolide put to the test: Tests on migraine models We used various migraine models to precisely measure the impact of parthenolide on brain activity and on nociceptive neurons, the latter being specifically dedicated to the transmission of pain signals. We monitored changes in neuronal activity patterns, with a particular focus on brain areas involved in pain perception and modulation. From theory to practice: A dedicated thesis These investigations formed the core of a doctoral thesis in neuroscience, allowing a young researcher to delve deeply into the study of parthenolide and its therapeutic potential. Through this rigorous and structured approach, we were able to confirm in a scientific and detailed manner the promising effects of this molecule. Encouraging results: Parthenolide reduces activity of pain neurons The results obtained were very encouraging. Parthenolide demonstrated its ability to significantly reduce the activity of nociceptive neurons, thus translating into a reduction in the nerve impulse responsible for the painful sensation. In the context of migraines, this materialized into a notable attenuation of the intensity of the attacks, thus opening the way to a new therapeutic strategy that could be revolutionary for the millions of people affected by this condition. Next steps: Towards clinical application With these promising results, we are now planning to continue our research to evaluate the safety and efficacy of parthenolide in humans, with a view to future clinical application. Our ultimate goal is to be able to offer a natural and effective alternative to people suffering from migraines, allowing them to regain control of their daily lives. By enriching the content and structuring it in a way that guides the reader through the different stages of the study, I hope to have contributed to making the second article more complete and understandable for the general public.
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Parthenolide: a role in pain modulation
TRP receptors are present in all cells of our body and play a key role in the perception of various external stimuli. Among this large family of receptors, some such as TRPA1 and TRPV1 are directly involved in the transmission of the pain signal. Many studies have therefore focused on finding ways to block these specific receptors, with the aim of reducing the painful sensation. How do TRP receptors work in pain transmission? These receptors act as messengers, transmitting signals to the brain when stimulated. This stimulation triggers an inflammatory response that is the cause of the pain felt. Blocking TRPA1 and TRPV1 receptors therefore appears to be a promising strategy to alleviate inflammation and, consequently, pain. However, TRP receptor antagonists, molecules designed to block them, have proven to be ineffective so far. One reason could be that cells produce more receptors when some of them are blocked, thus cancelling out the effect of the antagonist. Parthenolide: A potential solution from nature Parthenolide is a molecule found in small amounts in certain plants, such as butterbur or feverfew. Unlike classic antagonists, parthenolide has the ability to change the three-dimensional shape of the TRP receptor, making it less sensitive and, therefore, less able to transmit the pain signal to the brain. This process, called desensitization, also prevents the cell from producing new receptors, thus offering a potentially more effective and lasting solution. Progress of our laboratory on the subject In our lab, we conducted in vitro experiments to study how parthenolide interacts with the TRP receptor and how it alters its three-dimensional structure. This preliminary work confirmed that parthenolide does indeed bind to the receptor and paved the way for further research to explore its therapeutic potential as a natural treatment for pain. Read: Our article on the role of TRP receptors in migraine
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Study of 5-HTP: precursor of serotonin for fibromyalgia
Fibromyalgia , a disease that affects a growing number of people and remains a medical challenge, is at the heart of Naturveda's research efforts. In partnership with the Clermont-Ferrand University Hospital, we have launched another innovative project, this time focused on the study of plant active ingredients and their role in the modulation of pain in patients with fibromyalgia. Objectives and Hypotheses This project, parallel to our research on natural active ingredients such as vitamins and minerals, focuses on plant components, in particular those containing 5HTP (precursor of serotonin) . Our hypothesis is that these plants could offer a complementary or alternative therapeutic route to relieve the symptoms associated with fibromyalgia. The Importance of Serotonin and 5HTP Serotonin , often called the happiness hormone , plays a crucial role in regulating mood, sleep, and pain . Abnormal serotonin levels are often associated with fibromyalgia symptoms, such as depression and sleep problems. 5HTP , as a precursor to serotonin, has the potential to regulate these levels and, therefore, modulate pain and other symptoms. This makes it a particularly interesting research target for our study. Preliminary Results and Implications Although the project is still ongoing, initial results are encouraging. Herbs containing 5HTP show significant potential in regulating fibromyalgia symptoms . As with our previous project, these discoveries could lead to the formulation of a new herbal treatment, offering a natural alternative to the synthetic drugs currently available. Partnership and Collaboration Our collaboration with the Clermont-Ferrand University Hospital continues to play an essential role in the scientific validation of our research. This partnership ensures that our discoveries are not only innovative but also practically applicable in a medical setting. Conclusion Naturveda's efforts to explore the potential of plant actives in the treatment of fibromyalgia represent a promising step forward in our quest to better understand and treat this disease. With special attention to the role of 5HTP and serotonin, we hope to make a significant contribution to the lives of fibromyalgia patients.
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Analysis of natural assets against fibromyalgia pain
Fibromyalgia is a complex and often misunderstood condition that affects millions of people around the world. Characterized by chronic muscle pain , persistent fatigue and sleep disturbances , it has long been a medical mystery. At Naturveda, our innovative research laboratory, we work closely with Clermont-Ferrand University Hospital to lift the veil on this debilitating condition. One of our flagship projects focuses on the study of natural active ingredients and their impact on fibromyalgia. Objectives and Hypotheses Launched in 2022 for a duration of two years, the project seeks to understand how different natural compounds such as trace elements, vitamins, minerals and essential amino acids can modulate the pain felt by patients with fibromyalgia. Our initial hypothesis is that these compounds could play a crucial role in the regulation of symptoms, thus offering an alternative or complement to traditional pharmacological treatments. Preliminary Results and Implications Current research is promising. We have already gathered substantial evidence on the effectiveness of certain compounds, including magnesium, tryptophan and zinc. These discoveries made it possible to formulate the " FM complex ", a natural treatment specially designed for fibromyalgia patients. This complex could represent a significant advance in the treatment of fibromyalgia, offering potentially less invasive and more durable solutions than current options. Although further studies are needed to validate these results, the implications for patients could be revolutionary: reduced pain, improved quality of life, and perhaps even a better understanding of the disease itself. Partnership and Collaboration The collaboration with the Clermont-Ferrand University Hospital not only allows us to access specialized resources and skills, but also to conduct rigorous clinical trials. This partnership is essential to ensure the reliability and applicability of our findings. Conclusion The work being done at Naturveda as part of this project is helping to inform our understanding of fibromyalgia and paving the way for more effective and natural treatments. By focusing our research efforts on natural actives, we hope to demonstrate that nature itself can offer powerful solutions to the most complex medical challenges.
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