Link between sex hormones and migraine
November 16, 2022
New research published in November 2022 highlights the key role of sex hormones in migraine , especially in women. These results enrich the data of...
Mitochondrial dysfunction implicated in migraines
November 10, 2020
In the 1930s, it was suggested that migraine was associated with a decrease in blood sugar (Gray et al. 1935). Despite this hypothesis of the...
Invasive cortical depression: origin of migraine aura
Pervasive cortical depression: the origin of migraine aura? Pervasive cortical depression is probably the cause of the migraine aura. The more research advances, the more...
The descending paths of pain
November 9, 2020
Part 3 - Neuro-vascular hypothesis The descending paths of pain The descending pain pathways (figure 3) make it possible to modulate the nociceptive response, either...
Alteration of the trigeminal sensory complex and ascending pathways
Part 2 - Neurovascular hypothesis: Alteration of the trigeminal sensory complex and ascending pathways A. Sensitization of the trigeminal sensory complex When sensitization of the...
The neurovascular hypothesis to explain headaches
1. Periphery: neurogenic inflammation, sensitization of nociceptors For a long time, several theories described migraine as a vascular disorder with headache attributed solely to the...
The PACAP & VIP of inflammatory neuropeptides
The adenylate cyclase activating polypeptide (PACAP) is a neuropeptide involved in migraine discovered in 1989, thanks to its ability to stimulate the formation of cAMP...
The ascending paths of pain
Nociceptive information from the meninges and their vessels is relayed via ascending pathways , from the trigeminal sensory complex to the brainstem and diencephalon (Figure...
Anatomy of the trigeminovascular system
The trigemino-vascular system, its role in migraine In a few simple words: The trigeminovascular system is an essential component in the pathophysiology of migraine ....
Dysfunction of the hypothalamus
November 4, 2020
Hypothalamus involved in migraine The hypothalamus located in the central nervous system plays an essential role in the release of endocrine hormones. It is a...
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