Other treatments for migraine
November 12, 2020
There are a multitude of treatments used in migraine prophylaxis, but few of them have been properly evaluated methodologically. 1. Angiotensin II converting enzyme inhibitors...
Understanding migraine: the role of TRP receptors
TRP receptors were discovered only about ten years ago. Divided into several subfamilies, TRP receptors govern cellular behavior following a stimulus. Some of them, TRP-A1,...
Basic treatment for migraine
November 11, 2020
The main objective of basic treatment , also called prophylactic treatment, is to reduce the frequency of attacks, then their intensity. It is therefore not...
Non-specific migraine attack treatment
The purpose of migraine attack treatment is to reduce the intensity and duration of the attack when it occurs. There are specific treatments (ie developed...
Coenzyme Q10 & Magnesium for Migraine
November 10, 2020
Coenzyme Q10 There are other arguments supporting the idea of mitochondrial damage in the pathophysiology of migraines: monoamine oxidase, succinate dehydrogenase, NADH dehydrogenase (which works...
Mitochondrial dysfunction implicated in migraines
In the 1930s, it was suggested that migraine was associated with a decrease in blood sugar (Gray et al. 1935). Despite this hypothesis of the...
Invasive cortical depression: origin of migraine aura
Pervasive cortical depression: the origin of migraine aura? Pervasive cortical depression is probably the cause of the migraine aura. The more research advances, the more...
Glucose influences migraine. Hypoglycemia and diabetes
Le lien entre glycémie, migraine et diabète révèle des pistes intéressantes pour comprendre et prévenir les crises migraineuses grâce à une alimentation adaptée. ...
Vascular hypothesis of migraine attacks
November 9, 2020
Many debates on the origin of headache: the vascular theory The vascular theory of migraine attacks has been debated for a very long time. During...
Serotonin implicated in migraine
Serotonin and migraine Various studies have implicated serotonin in migraine. Serotonin constricts nerve endings and blood vessels and thus affects pain. The team of Comings...
The descending paths of pain
Part 3 - Neuro-vascular hypothesis The descending paths of pain The descending pain pathways (figure 3) make it possible to modulate the nociceptive response, either...
Alteration of the trigeminal sensory complex and ascending pathways
Part 2 - Neurovascular hypothesis: Alteration of the trigeminal sensory complex and ascending pathways A. Sensitization of the trigeminal sensory complex When sensitization of the...
The neurovascular hypothesis to explain headaches
1. Periphery: neurogenic inflammation, sensitization of nociceptors For a long time, several theories described migraine as a vascular disorder with headache attributed solely to the...
The PACAP & VIP of inflammatory neuropeptides
The adenylate cyclase activating polypeptide (PACAP) is a neuropeptide involved in migraine discovered in 1989, thanks to its ability to stimulate the formation of cAMP...
Calcitonin Gene-Related Peptide CGRP in Migraine
Discovery of CGRP In 1985, researchers discovered that something called CGRP could be linked to migraines. CGRP is a hormone that helps control calcium in...
The ascending paths of pain
Nociceptive information from the meninges and their vessels is relayed via ascending pathways , from the trigeminal sensory complex to the brainstem and diencephalon (Figure...
Anatomy of the trigeminovascular system
The trigemino-vascular system, its role in migraine In a few simple words: The trigeminovascular system is an essential component in the pathophysiology of migraine ....
Migraine Complications
November 4, 2020
Chronic headaches : It occurs in a migraine patient whose headache is present for 15 days or more per month, for more than 3 months...
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